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作者复制了家兔病理性氧供依赖性(POSD)模型。采用渐进性低氧法降低总氧运输量(TO_2),从而考察机体氧运输及氧摄取的变化特点。结果表明,在TO_2-VO_2的关系中,对照组可清楚地分为“非依赖”与“依赖”两部分;内毒素组从呼吸空气开始,从未出现坪区,内毒素组和对照组依赖段的斜率,即氧提取率分别为0.473和0.730,两者差别显著(P<0.05)。内毒素组的动静脉血氧含量差值(CaO_2-CVO_2)在渐进性低氧过程中逐渐变小(P<0.01,ANOVA),对照组则呈相反变化趋势,故其组间差别越来越大,表明内毒素组氧提取率降低。
The authors copied a rabbit pathological oxygen-dependent (POSD) model. Gradual hypoxia was used to reduce the total oxygen transport (TO_2), so as to investigate the changes of oxygen transport and oxygen uptake. The results showed that in TO_2-VO_2 relationship, the control group can be clearly divided into “independent” and “dependent” parts; the endotoxin group started from the respiratory air, never appeared Ping area, endotoxin group and the control group dependent The slopes of the sections, ie, the oxygen extraction rates were 0.473 and 0.730, respectively, with significant differences (P <0.05). In the endotoxin group, the difference of arterial and venous blood oxygen content (CaO_2-CVO_2) gradually decreased during progressive hypoxia (P <0.01, ANOVA) while the control group showed the opposite tendency, so the difference between the groups became more and more Large, indicating that the endotoxin group oxygen extraction rate decreased.