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目的分析巨幼细胞性贫血的常见病因、发病年龄、生活背景及其与膳食异常的关系。贫血程度及其与白细胞和血小板三系例之间的关系。方法对64例经骨髓象确诊的巨幼细胞性贫血患者同时检测血液常规,并对临床及实验资料作回顾性分析。结果消化系统器质性病变12例,单纯膳食异常43例,妊娠妇女3例,甲状腺功能减退3例,3例未发现明确病因。31例膳食异常的原因有口腔疾患、生活背景、不良生活方式。结论膳食异常是现代营养性巨幼细胞性贫血的常见病因,发病以中老年人居多,女性多于男性,贫血多为中重度,半数以上患者周围血可表现为两系例或三系例减少。
Objective To analyze the common causes of megaloblastic anemia, the age of onset, the life background and its relationship with dietary abnormalities. Anemia and its relationship with leukocyte and platelet triad cases. Methods A total of 64 patients with megaloblastic anemia confirmed by bone marrow imaging were enrolled in this study. The clinical data and laboratory data were retrospectively analyzed. Results There were 12 cases of organic disease of digestive system, 43 cases of simple dietary abnormality, 3 cases of pregnant women, 3 cases of hypothyroidism and 3 cases of definite etiology. The causes of abnormal diet in 31 cases were oral diseases, life background and bad life style. Conclusions Dietary abnormalities are the common cause of modern nutritional megaloblastic anemia. The incidence of middle-aged and elderly patients is more than that of males, and the majority of anemia is moderate-severe. More than half of the patients with peripheral blood can be reduced to two-series or three-series cases .