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目的:探讨IL12B基因多态性与女性卵巢癌的关系。方法:采用PCR-RFLP技术检测92例卵巢癌患者与38例正常对照者IL12B rs3212227基因多态性。结果:IL12B基因型频率分布在病例组和对照组人群中的差异无统计学意义(p=0.086)。非变异基因型IL12B rs3212227AA与变异基因型IL12B rs3212227AC/CC在两组人群中的分布差异具有显著性(p=0.036),而与AA基因型相比,AC/CC基因型能显著提高卵巢癌的患病风险(OR=2.47;95%可信区间为1.05-5.84)。结论:本研究结果提示,IL12B rs3212227基因多态性与卵巢癌的患病风险有关,其变异提高卵巢癌的发病率,是卵巢癌的危险因子之一。
Objective: To investigate the relationship between IL12B gene polymorphism and female ovarian cancer. Methods: The polymorphisms of IL12B rs3212227 in 92 patients with ovarian cancer and 38 normal controls were detected by PCR-RFLP. Results: There was no significant difference in the frequency of IL12B genotype between the case group and the control group (p = 0.086). The distribution of non-variant genotype IL12B rs3212227AA and variant genotype IL12B rs3212227AC / CC were significantly different between the two groups (p = 0.036). However, compared with AA genotype, the AC / CC genotype could significantly increase the ovarian cancer Sickness risk (OR = 2.47; 95% confidence interval 1.05-5.84). Conclusion: The results of this study suggest that IL12B rs3212227 gene polymorphism is associated with the risk of ovarian cancer, and its mutation increases the incidence of ovarian cancer and is one of the risk factors of ovarian cancer.