[Objective] To compare the increasing effects of CAULIS SPATHOLOBI and COLLA CORII ASINI on white blood cell(WBC)in rats. [Method] Rats were given 100 mg/kg cyclophosphamide (CTX) subcutaneously in order to establish the low WBC model of rats. On the 7th, 9th and 11th days of administration of CAULIS SPATHOLOBI, blood samples of rats were collected. The WBC count and its classified proportion were detected and analyzed. [Result] The CAULIS SPATHOLOBI high- and middle-dosage groups (12.15, 4.05 g/kg) had significant increasing effects on rats WBC, as well as the COLLA CORII ASINI high- and low-dosage groups (7.29, 2.43 g/kg). There was no statistical significance in the WBC count between CAULIS SPATHOLOBI group and COLLA CORII ASINI group at the same multiple clinical equivalent dosage. [Conclusion] Both CAULIS SPATHOLOBI and COLLA CORII ASINI had significant increasing effects on the WBC reduction induced by chemotherapeutic drugs; and their effects were equivalent. [Method] Rats were given 100 mg / kg cyclophosphamide (CTX) subcutaneously in order to establish the low WBC model of rats. [Objective] To compare the increasing effects of CAULIS SPATHOLOBI and COLLA CORII ASINI on white blood cells (WBC) in rats. . The WBC count and its classified proportion were detected and analyzed. [Result] The CAULIS SPATHOLOBI high- and middle-dosage groups (12.15, 4.05 g / kg) had significant increasing effects on rats WBC, as well as the COLLA CORII ASINI high- and low-dosage groups (7.29, 2.43 g / kg). There was no statistical significance in the WBC count between CAULIS SPATHOLOBI group and COLLA CORII ASINI group at the same multiple clinical equivalent dosage. [Conclusion] Both CAULIS SPATHOLOBI and COLLA CORII ASINI had significant increasing effects on the WBC reduction induced by chemotherapeutic drugs; and their effects were equivalent.