论文部分内容阅读
美国西奈山医学院的科学家们认为,在某些遗传性神经疾病(如帕金森氏震颤性麻痹症和亨丁顿氏舞蹈病)中脑细胞的死亡是由于缺乏谷氨酸脱氢酶(见“Science”Vol. 216, P193)。患有小脑萎缩症的病人,其脑部位中控制精细运动的神经细胞也由于缺乏谷氨酸脱氢酶(以下简称GDH)而死亡,最后导致全身丧失肌肉控制和协调。 GDH与血中谷氨酸的浓度息息相关。缺乏GDH,血中积累起来的谷氨酸就不能除去。血中高浓度的谷氨酸并不直接影响脑,因为谷氨酸并不能跨
Scientists at Mount Sinai School of Medicine believe brain cell death in certain hereditary neurological diseases such as Parkinson’s and Parkinson’s disease is due to a lack of glutamate dehydrogenase (see Science, Vol. 216, p 193). Patients with cerebellar atrophy also have nerve cells that control fine motor activity in their brains also died of a deficiency of glutamate dehydrogenase (GDH), which eventually leads to loss of muscle control and coordination throughout the body. GDH and blood glutamate concentration is closely related. Lack of GDH, the accumulation of glutamate in the blood can not be removed. High blood glutamate does not directly affect the brain, because glutamate does not cross