Objective:To systematically evaluate the efficacy and safety of traditional Chinese medicine in the treatment of arrhythmia combined with anxiety and depression by meta analysis. Methods: Chinese and foreign medical literature databases such as CNKI, Wanfang, VIP, PubMed and The Cochorane Library were searched by computer until September 2020. Collect all the published clinical randomized controlled trials of traditional Chinese medicine(TCM) in the treatment of arrhythmia combined with anxiety and depression. The risk assessment tools provided by Cochrane were used to evaluate the quality of the studies,and meta analysis was carried out by Revman 5.3 software. Results: 17 studies were included, with a total sample of 1773 cases, including the experimental group useing traditional Chinese medicine with western medicine therapy (n = 888), and the control group using simple routine western medicine treatment(n = 885). The results of Meta analysis showed that: compared with the control group (western medicine), the experimental group (traditional Chinese medicine combined with western medicine) can significantly improve the curative effect of TCM syndrome [RR=1.28 (1.19,1.39)], decrease the number of attacks for arrhythmia [RR=1.29 (1.21,1.36)], reduce the score of anxiety[RR=-1.44 (-2.09,-0.78)] and depression scale[RR=-0.94 (-1.34,-0.53)],the differences were statistically significant. Conclusion: Traditional Chinese medicine has significant clinical effect in the treatment of arrhythmia combined with anxiety and depression, and the adverse reaction is mild, which is better than the simple use of western medicine, but more rigorous high-quality clinical RCTs are needed for further verification.