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1例69岁女性高血压病患者因脑外伤后肌痉挛给予替扎尼定口服。用药前血压135~174/73~90 mm Hg(1 mm Hg=0.133 kPa),心率60~80次/min。替扎尼定剂量增至4 mg、3次/d的第2天,患者心率降至45次/min,停用替扎尼定。次日,患者血压180/100 mm Hg,心率120次/min。予卡托普利、硝苯地平调整血压、心率,效果不佳。给予替扎尼定2 mg,约1 h后,患者血压124/69mm Hg、心率65次/min。20 d后,因患者下肢肌张力偏高再次给予替扎尼定2 mg。半小时后,血压降至60/40 mm Hg,应用间羟胺后血压恢复正常。次日血压再次升至180/100 mm Hg。予苯磺酸氨氯地平、厄贝沙坦、卡托普利、硝苯地平联合降压,血压逐渐稳定。
A 69-year-old female patient with hypertension was given tizanidine orally for muscle spasms after traumatic brain injury. Blood pressure before treatment 135 ~ 174/73 ~ 90 mm Hg (1 mm Hg = 0.133 kPa), heart rate 60 to 80 beats / min. Tizanidine dose was increased to 4 mg, 3 times / d on the 2nd day, the patient’s heart rate dropped to 45 beats / min, disable tizanidine. The next day, patients with blood pressure 180/100 mm Hg, heart rate 120 beats / min. To captopril, nifedipine to adjust blood pressure, heart rate, the effect is not good. Tizanidine given 2 mg, about 1 h, the patient’s blood pressure 124/69 mm Hg, heart rate 65 beats / min. After 20 days, tizanidine 2 mg was given again due to the higher muscle tone of the lower limbs. Half an hour later, the blood pressure dropped to 60/40 mm Hg, blood pressure returned to normal after the application of hydroxylamine. The next day the blood pressure rose again to 180/100 mm Hg. Amlodipine besylate, irbesartan, captopril, nifedipine combined blood pressure, blood pressure gradually stabilized.