卡巴醌(carboquone,CQ)是一种烷化剂,化学结构上有3个活性基团,即氮丙啶基、氨甲酰基和醌环。具有抗肿瘤活性,其化疗指数和延长生存期优于氨甲喋吟、丝裂霉素或环磷酰胺。作者采用卡巴醌和强的松龙(P)(CQ-P)联合治疗16例初治多发性骨髓瘤(MM),其中Ig-G型8例、Ig-A型5例、Ig-D型2例,仅本周氏蛋白1例。低危患者7例,其标准为:(1)血尿素氮<0.3g/L;(2)血清钙<0.12g/L;(3)无明显感染;(4)白细胞数>4×10~9/L,血小板数>100×10~9/L。疗程和用量为CQ0.06mg/kg/日,强的松龙1.5-2.0mg/kg/日,口服4天。根 Carbquone (CQ) is an alkylating agent with three active groups in its chemical structure, namely aziridinyl, carbamoyl and quinone rings. With anti-tumor activity, its chemotherapy index and prolonged survival is superior to the methotrexate Yin, mitomycin or cyclophosphamide. The authors used a combined treatment of ketopheone and prednisolone (P) (CQ) in 16 patients with multiple myeloma (MM), of which 8 were Ig-G, 5 were Ig-A, Ig-D 2 cases, only this week’s protein in 1 case. (1) blood urea nitrogen <0.3g / L; (2) serum calcium <0.12g / L; (3) no obvious infection; (4) white blood cell count> 4 × 10 ~ 9 / L, platelet count> 100 × 10 ~ 9 / L. Treatment and dosage CQ0.06mg / kg / day, prednisolone 1.5-2.0mg / kg / day, orally for 4 days. root