目的　应用去氧胆酸钠诱发香猪重症急性胰腺炎 (severe acute pancreatitis,SAP)模型 ,观察粉防己碱、清胰汤对 SAP香猪血胃肠激素水平的影响。　方法　用 32只贵州香猪 ,雌雄不拘 ,随机分为 4组 :生理盐水 (NS)对照组 ;粉防己碱 (tetrandrine,Tet)组 ;中药清胰汤 (chinese medicine qing yitang,CMQ)组 ;Tet+ CMQ联合组。各组受试动物术前禁食 12 h,禁水 6 h,无菌手术行门静脉、腔静脉插管 ,经胰管逆行加压推注 5 %去氧胆酸钠 (0 .5 ml/ kg体重 )复制 SAP模型 ,制模后 1h静脉滴注 NS或相应药物、胃管推注 NS或相应药物。分别于制模前 ,制模后 1h、6 h、12 h、2 4 h、4 8h、72 h、96 h同时采门静脉血和中心静脉血 ,分离血浆或血清 ,用放免法检测血浆胃动素和血清胃泌素水平 ;记录观察时间内 (96 h)各组动物的死亡率 ;取第 96小时动物的胰腺、十二指肠 ,作常规病理检查。　结果　与 NS组相比 ,粉防己碱、清胰汤均可降低 SAP香猪 96 h内的死亡率 ;可显著降低各时间点门静脉、中心静脉(除制模前、制模后 1h外 )血清胃泌素的浓度 (P<0 .0 1) ,可增加血浆胃动素的浓度 (P<0 .0 1) ;作用效果二者相当 (P>0 .0 5 ) ,而联合组的作用更为显著 (P<0 .0 1或 P<0 .0 5 )。用药组的胰腺、十二指肠病理变化也较 NS组明 Objective To study the effect of sodium deoxycholate on severe acute pancreatitis (SAP) in pigs and to observe the effects of tetrandrine and Qingyi Decoction on the serum levels of gastrointestinal hormones in SAP. Methods 32 Guizhou pigs were randomly divided into 4 groups: normal saline (NS) control group, tetrandrine (Tet) group, traditional Chinese medicine qing yitang (CMQ) group, Tet + CMQ joint group. The animals in each group were fasted for 12 h before operation for 6 h. All patients underwent aseptic surgery with portal vein and vena cava cannula. The rats were anesthetized with 5% deoxycholate (0. 5 ml / kg Weight) SAP model replication, 1h after injection of NS model or the corresponding drug, gastric tube injection of NS or the corresponding drug. The venous blood and central venous blood were collected at the same time before modeling, 1 h, 6 h, 12 h, 24 h, 48 h, 72 h, 96 h after model establishment, respectively. Superoxide dismutase and serum gastrin levels were recorded. The mortality of animals in each group was recorded during the observation period (96 hours). The pancreas and duodenum of the 96th hour animals were taken for routine pathological examination. Results Compared with the NS group, tetrandrine and Qingyi Decoction could reduce the mortality of SAP Xiang pigs within 96 h, and significantly reduce the serum levels of portal vein, central vein (except 1 h after model making and 1 h after model establishment) The concentration of gastrin (P <0.01) increased the concentration of plasma motilin (P <0.01), and the effect was similar (P> 0.05), while the effect of combination group More significant (P <0. 01 or P <0. 05). The pancreas and duodenal pathological changes in the medication group were also better than those in the NS group