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目的探讨康妇炎胶囊联合苦参碱栓治疗阴道炎的临床疗效。方法收集海南省临高县人民医院2015年2月—2016年2月收治的阴道炎患者84例,按照治疗方法的不同分成对照组和治疗组,每组各42例。对照组使用苦参碱栓,1次/d。治疗组在对照组的基础上口服康妇炎胶囊,3粒/次,2次/d。两组患者均连续治疗14 d。观察两组的临床疗效,同时比较治疗前后两组的白带减少、外阴瘙痒消失、外阴阴道疼痛消失和黏膜充血消失的时间,以及白细胞介素-2(IL-2)、IL-8和IL-13水平的变化情况。结果治疗后,治疗组的总有效率(95.24%)明显高于对照组(80.95%),两组总有效率比较差异有统计学意义(P<0.05);治疗组治疗后的白带减少、外阴瘙痒消失、外阴阴道疼痛消失和黏膜充血消失的时间均比对照组短,两组比较差异具有统计学意义(P<0.05)。两组患者阴道灌洗液中IL-2、IL-8和IL-13水平显著降低,同组治疗前后差异具有统计学意义(P<0.05);治疗组治疗后的上述炎性因子降低更明显,与对照组治疗后的比较差异具有统计学意义(P<0.05)。结论康妇炎胶囊联合苦参碱栓治疗阴道炎效果显著,可明显改善患者临床症状和减轻炎症反应。
Objective To investigate the clinical effect of Kang Fu Yan capsule combined with matrine suppository in the treatment of vaginitis. Methods Eighty-four patients with vaginitis admitted from January 2015 to February 2016 in Linggao County People’s Hospital of Hainan Province were divided into control group and treatment group with 42 cases in each group according to different treatment methods. Control group using matrine suppository, 1 / d. Treatment group in the control group based on oral Kang Fu Yan capsules, 3 capsules / time, 2 times / d. Two groups of patients were treated for 14 days. The clinical efficacy of the two groups were observed. The leucorrhea was reduced, the genital itching disappeared, the disappearance of vulvovaginal pain and disappearance of mucosal congestion were observed in both groups before and after treatment, and the levels of interleukin-2 (IL-2), IL-8 and IL- 13 levels of change. Results After treatment, the total effective rate (95.24%) in the treatment group was significantly higher than that in the control group (80.95%), the total effective rate was significantly different between the two groups (P <0.05) The disappearance of pruritus, disappearance of vulvovaginal pain and disappearance of mucosal congestion than the control group, the difference between the two groups was statistically significant (P <0.05). The levels of IL-2, IL-8 and IL-13 in the vaginal lavage fluid of the two groups were significantly lower than those in the control group (P <0.05). The reduction of inflammatory factors in the treatment group was more obvious , Compared with the control group after treatment was statistically significant (P <0.05). Conclusion Kang Fuyan capsules combined with matrine suppository treatment of vaginitis significantly, can significantly improve the clinical symptoms and reduce inflammation.