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本文报道2例全身性红斑狼疮(SLE)病程中发生非何杰金氏淋巴瘤。例1,15岁,系在英国出生的西印地安女孩。1974年有游走性关节炎及发热,后面部发生蝴蝶形疹和脱发。Hb 为10.3g/dl,血沉(魏氏法)106mm/h,抗核因子(ANF)强阳性,狼疮细胞阳性,故诊断为 SLE.以强的松龙治疗,疗效好。1978年11月患者颈、腋及腹股沟出现无痛性淋巴结肿大.活检为弥散性原始淋巴细胞性淋巴瘤.遂以长春新碱、阿霉素及强的松龙(V-AP)联合方案治疗,淋巴结肿大消散。1979年3月用6-MP、氨甲蝶呤、环磷酰胺和强的松龙维持治疗以后,情况保持良好。
This article reports two cases of non-Hodgkin’s lymphoma in the course of systemic lupus erythematosus (SLE). Example 1, 15 years old, a West Indies girl born in the United Kingdom. In 1974 there are migratory arthritis and fever, the back of the butterfly rash and hair loss. Hb 10.3g / dl ESR 106mm / h, anti-nuclear factor (ANF) strongly positive, positive lupus cells, it is diagnosed as SLE. Treatment with prednisolone, good effect. November 1978 patients with neck, axillary and groin painless lymphadenopathy. Biopsy for diffuse idiopathic lymphoblastic lymphoma, then vincristine, doxorubicin and prednisolone (V-AP) combined with the program Treatment, swollen lymph nodes dissipate. After maintenance treatment with 6-MP, methotrexate, cyclophosphamide and prednisolone in March 1979, the condition remained good.