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探讨儿童急性白血病继发输血后丙型病毒性肝炎的发生、发展及转归。方法 用RT PCR法测血清HCV RNA ,并用ELISA方法测HCV核心区多肽抗体 (HCV CP)。结果 10 7例儿童白血病中HCV感染率达 70 % (75 10 7) ;HCV CP检测阳性率明显低于HCV RNA(40 %vs74% ) ;HCV感染者化疗期间曾有转氨酶 (ALT)明显升高 ,但停止化疗后 5 0例中仅 1例ALT持续偏高 ,余均恢复正常 ,随访 0 .5a至 9a未发现肝功能失代偿表现。结论 儿童白血病继发HCV感染率高 ,但感染后多未呈进行性活动性肝炎表现 ,也未见肝功能失代偿发生 ;化疗期间HCV RNA检测优于HCV CP。
To investigate the occurrence, development and prognosis of hepatitis C after secondary transfusion of acute leukemia in children. Methods The serum HCV RNA was detected by RT PCR and HCV core region antibody (HCV CP) was detected by ELISA. Results The positive rate of HCV infection in 70 children with leukemia was 70% (75 10 7). The positive rate of HCV CP was significantly lower than that of HCV RNA (40% vs 74%). ALT was significantly increased in HCV-infected patients during chemotherapy , But only one case of ALT remained high after stopping chemotherapy in 50 cases, all of them returned to normal. No manifestation of hepatic decompensation was found at 0.5 to 9 years of follow-up. Conclusions The HCV infection rate of childhood leukemia secondary to HCV infection is high. However, no progressive active hepatitis was found after infection, and hepatic decompensation was not observed. HCV RNA detection was superior to HCV CP during chemotherapy.