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为了解儿童因药源性疾病入院的现状,对1578例儿科住院病人进行了一次回顾性药物流行病学调查.结果表明:①有23例因药源性疾病入院,占全部儿科住院病的146%;②引起药源性疾病的药物包括解热镇痛药、抗生素、磺胺类、中药及外用药,药物种类及病例数均以解热镇痛药居首位,其次为抗生素;③临床表现的前三位依次为药疹、药物性血尿和青霉素过敏;④23例中死亡1例,病死率为4.35%;⑤解热镇痛药的非处方应用及抗生素的不合理应用是导致儿童药源性疾病入院的重要原因.
A retrospective epidemiological survey of 1,578 pediatric inpatients was conducted to understand the status of children admitted to hospital due to drug-induced diseases. The results showed that: (1) 23 cases were hospitalized due to drug-induced diseases, accounting for 146% of all pediatric inpatients %; ② Drugs causing drug-induced diseases include antipyretic and analgesic drugs, antibiotics, sulfonamides, traditional Chinese medicines and external drugs, the number of drugs and the number of cases are the top antipyretic and analgesic drugs, followed by antibiotics; ③ clinical manifestations Of the top three followed by drug eruptions, drug-induced hematuria and penicillin allergy; ④23 cases of death in 1 case, the case fatality rate was 4.35%; ⑤ antipyretic analgesics over-the-counter use and antibiotics unreasonable application of lead to drug-induced children An important reason for hospitalization.