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目的探讨哮喘急性发作期患儿血清趋化因子CCL18水平变化及意义。方法将52例支气管哮喘急性发作患儿按病情严重程度分为轻、中、重组,采用ELISA法检测各组治疗前后血清CCL18水平,同时与10例正常人血清CCL18水平作对照。结果中度、重度组治疗前血清CCL18水平明显高于对照组(P<0.01),结论血清CCL18的水平可能与哮喘急性发作的严重程度有关;其在哮喘发病及病情判断中可能起重要作用。
Objective To investigate the changes of serum chemokine CCL18 in children with acute asthma and its significance. Methods Fifty-two children with acute exacerbation of bronchial asthma were divided into mild, moderate and severe cases according to the severity of the disease. The levels of serum CCL18 in each group before and after treatment were detected by ELISA, and the serum CCL18 levels in 10 normal people were compared. Results The level of serum CCL18 in moderate and severe group before treatment was significantly higher than that in control group (P0.01). Conclusion The level of serum CCL18 may be related to the severity of acute exacerbation of asthma. It may play an important role in the pathogenesis of asthma.