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作者曾证明一种LRF的高活性类似物,第6位D构型色氨酸,第10位去甘氨酸的LRF的乙基酰胺(LRF-Ag),在妇女黄体期时注射1或2天能引致黄体溶解。本文试图阐明内源性或外源性H-CG对LRF-Ag溶黄体作用的影响。在4例月经周期规律的妇女,于1个对照周期后,第二个周期的黄体期中期给每例受试者皮下注射50μg LRF-Ag,连用两天;第三个周期时,与注射LRF-Ag同时,3例受试者配用5,000IU HCG,1例配用100IU HCG,均连续用HCG 6天。取血,用放射免疫分析法分别测定LH、孕酮、雌二醇及β-HCG。
The authors have demonstrated that LRF, a highly active analogue of LRF, isotype 6, D-form tryptophan, LRF-Ag at position 10, is injected in the luteal phase of women for 1 or 2 days Cause luteal lysis. This article attempts to elucidate the effect of endogenous or exogenous H-CG on the effects of LRF-Ag lutein. In 4 women with regular menstrual cycles, each subject was injected subcutaneously with 50 μg of LRF-Ag for 1 day after the 1 cycle of control and mid-luteal phase of the second cycle for 2 days. In the third cycle, -Ag At the same time, 3 subjects with 5,000 IU HCG, 1 case with 100IU HCG, HCG continuous use of 6 days. Blood samples were taken for determination of LH, progesterone, estradiol and β-HCG by radioimmunoassay.