本文资料证实助阳药附子或附子加肉桂(附桂)明显地增高二肾一夹型高血压大鼠的血压。对该模型 PRA、ACE 和 UKa 浓度的影响,助阳药附子或附桂与滋阴药六味地黄方之间无有意义的区别。但助阳药附子却明显地增高 UA 的排出(P<0.001),六味地黄方则不改变它的排出。这和对血压的观察一样,提示二肾一夹型高血压大鼠可能为中医的“阴虚”模型。 The data in this article confirmed that the Astragalus Aconite or Aconite plus Cinnamon (Attached Gui) significantly increased the blood pressure of the two-kidney and one-clip hypertensive rats. There was no significant difference between the concentration of PRA, ACE, and UKa in the model, and between the Astragalus mongholicus or Fugui and Ziyin Liuweidihuang. However, Aconite Aconite obviously increased the discharge of UA (P<0.001), and Liuweidihuang did not change its discharge. This is similar to the observation of blood pressure, suggesting that two-kidney, one-clip type hypertensive rats may be a “negative” model of traditional Chinese medicine.