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文献曾报告多巴胺在治疗休克时对心血管及肾脏明显有益,表现为增加心排出量,升高血压,使小动脉松弛以促进器官组织灌注,增加排钠、尿量及肾血流量。而对脓毒性或内毒素性休克,单独应用多巴胺的作用就很差。作者用狗失血性低血压(70 mmHg)的模型研究多巴胺对肾脏功能和血流动力学的影响。用杂种狗,体重24±1 kg,在氯醛麻醉下,行左股动脉插管按金属Y形管,一头接压力传感器测动脉血压,另一头用
Literature has reported dopamine in the treatment of shock on the cardiovascular and renal obvious benefits, manifested as increased cardiac output, increased blood pressure, the arterioles to relax in order to promote organ perfusion and increase sodium, urine output and renal blood flow. For septic or endotoxic shock, the role of dopamine alone is poor. The authors studied the effects of dopamine on renal function and hemodynamics using a model of dog hemorrhagic hypotension (70 mmHg). With a hybrid dog, weighing 24 ± 1 kg, under chloraldehyde anesthesia, left femoral artery cannulation by metal Y-shaped tube, a pressure sensor to measure arterial blood pressure, the other with