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患者女性,49岁,干部。因高血压3年伴嗜睡、肥胖2年于1984年4月27日入院。3年前感觉头昏、头痛,测血压高达180/120mmHg,服用利血平有效。近2年来出现嗜睡,睡眠时间明显延长,每天16～20h,伴体重逐渐增加,近半年更著,增加15kg,食欲佳,伴心慌、多汗、气急,疲乏无力,脾气急躁,健忘,性欲减退,视力下降,发病以来无多饮、多尿、抽搐,在外院先后作口服葡萄糖耐量试验,24h尿17-O HCS(17羟类固醇)、17 KS(17酮类固醇)、ACTH兴奋试验均无异常,FSH(卵泡刺激素)>26.4小白鼠子宫单位,颅片:蝶鞍骨质吸收,疑垂体瘤,脑血管造影(—),因诊断不明来沪就诊。4年来冬季有咳嗽、咳痰,不喘。出生于安徽,16岁到云南,无烟酒嗜好,月经一年来周期延长,末次月经1981年12月,生育二女一子均健康,无高血压、嗜睡、肥胖家族史。
Patient female, 49 years old, cadre. 3 years due to hypertension with lethargy, obesity 2 years in April 27, 1984 admission. 3 years ago feeling dizzy, headache, measuring blood pressure up to 180 / 120mmHg, taking reserpine effective. Drowsiness, sleep time significantly increased in the past two years, 16 ~ 20h daily with body weight gradually increased in the past six months more, an increase of 15kg, good appetite, with palpitation, hyperhidrosis, shortness of breath, fatigue, temper, forgetfulness, loss of libido , Visual acuity, no polyp, polyuria, convulsions since the onset of the disease, oral glucose tolerance test has been conducted outside the hospital, 24h urine 17-O HCS (17 hydroxysteroid), 17 KS (17 ketosteroids), ACTH excited test were normal , FSH (follicle stimulating hormone)> 26.4 mouse uterine unit, cranial films: sella bone absorption, suspected pituitary tumor, cerebral angiography (-), due to diagnosis is unknown to Shanghai treatment. 4 years in winter there is cough, sputum, not breath. Born in Anhui, 16 years old to Yunnan, non-smoking alcohol hobby, menstrual cycle extended in one year, the last menstrual December 1981, childbearing and child are healthy, no high blood pressure, lethargy, obesity family history.