论文部分内容阅读
目的评价国产重组乙肝疫苗酵母和重组ＣＨＯ乙肝疫苗阻断母婴传播效果。方法应用两种乙肝疫苗，对母亲ＨＢｓＡｇ和ＨＢｅＡｇ双阳性的新生儿进行免疫，并以国产血源乙肝疫苗作对照。结果国产酵母重组和ＣＨＯ重组乙肝疫苗具有较好的安全性，免疫第９、１２个月，阻断母婴传播的近期保护效果分别为１０００％和９６４％。结论上述两种国产基因重组乙肝疫苗与３０ｕｇ血源乙肝疫苗＋ＨＢＩＧ效果（９５０％）相同。
Objective To evaluate the effect of domestic recombinant hepatitis B vaccine and recombinant CHO hepatitis B vaccine in blocking mother-to-infant transmission. Methods Two kinds of hepatitis B vaccine were used to immunize newborns with both HBsAg and HBeAg positive mothers, and the domestic Hepatitis B vaccine was used as a control. Results Domestic Yeast Recombinant and CHO Recombinant Hepatitis B Vaccine had good safety. The short-term protective effect of blockage of mother-infant transmission at 9 and 12 months of immunization was 1000% and 964% respectively. Conclusion The above two domestic recombinant hepatitis B vaccines have the same effect as HBIG vaccine (950%) with 30ug blood.