TSAA-291是日本合成的一类新的抗雄激素药物的代表.1979年Acta Endocrin-ologica的增刊曾作专题报导。本文作一综合性介绍。 合成这一类药物的理论根据是类固醇分子具有雄激素样作用在结构上要求有17—羟基。如在其分子的适当位置上接上一个大的基团,产生空间位阻现象,就能影响这一作用,因而合成了这一类新的、副作用较少的抗雄激素药物。可用于治疗人的前列腺肥大、多毛症和痤疮等. [化学结构]TSAA—291及其衍生 TSAA-291 is a representative of a new class of anti-androgenic drugs synthesized in Japan, and a special supplement to the Acta Endocrin-ologica was published in 1979. This article for a comprehensive introduction. The rationale for the synthesis of this class of drugs is that steroid molecules have an androgen-like structure that requires 17-hydroxyl groups structurally. If the molecular position in a large group connected to produce steric hindrance phenomenon, can affect this effect, and thus the synthesis of this new, less side effects of anti-androgen drugs. Can be used to treat prostatic hypertrophy, hirsutism and acne, etc. [Chemical Structure] TSAA-291 and its derivatives