托瑞米芬是一种三苯乙烯衍生物,结构及作用机理与他莫昔芬相似。近年来,作为一种新型的抗雌激素药,运用于肿瘤辅助化疗方面,取得了较理想的临床效果。 一、药代动力学 托瑞米芬口服易吸收,在动物体内的生物利用度几乎为100％。在体内主要与白蛋白结合,小部分与β_1-球蛋白结合。托瑞米芬在人体内的半衰期为4小时,清除相为5天, Topiramate is a tristyryl derivative with similar structure and mechanism of action to tamoxifen. In recent years, as a new type of antiestrogen, it has been applied in the field of adjuvant chemotherapy and has achieved a satisfactory clinical effect. First, the pharmacokinetics toremifene oral absorption, in vivo bioavailability of almost 100%. In the body mainly with albumin binding, a small part of β 1-globulin binding. Toremifene in the human body half-life of 4 hours, clear phase for 5 days,