本文研制了盐酸雷尼替丁胃内滞留漂浮型缓释片剂(RSRT)。本品的体外溶出符合一级动力学过程:RSRT在胃内滞留时间5-6h,明显比普通对照片(2h内)长;RSRT体内以单室模型描述较适宜,RSRT体内为一级释药。药动学参数为:Ka=0.2550h~(-1),K=0.2765h~(-1),Vd=84.38L,t_(max)=3.77h,C_(max)=627.7ng/ml。本品的体内外数据具有显著相关性。 This article developed ranitidine hydrochloride intragastric floating sustained release tablets (RSRT). In vitro dissolution of this product is in accordance with the first-order kinetic process: the retention time of RSRT in the stomach is 5-6h, which is obviously longer than that of the normal control (within 2h); the single-compartment model of RSRT is more suitable in vivo and the first-grade RSRT . The pharmacokinetic parameters were as follows: Ka = 0.2550h -1, K = 0.2765h -1, Vd = 84.38L, t max = 3.77h, C max = 627.7ng / ml. This product in vivo data has significant correlation.