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目的:探析临床上应用米索前列腺预防孕产妇产后出血的效果和价值。方法:本研究回顾性分析我院2012年3月~2013年4月期间妇产科收治的180例孕产妇的临床资料,其中90例在分娩后静脉注射20U缩宫素为对照组,另外90例在分娩后口服600ug米索前列醇为观察组,对比观察两组患者第3产程的时间、产后2h和24h出血量、产后出血率、不良反应发生率,同时观察两组患者用药前后心率、血压的变化情况。结果:两组患者用药前后心率、血压无明显改变(P>0.05);观察组第三产程时间、2h和24h出血量明显少于对照组(P<0.05),产后出血率明显低于对照组(P<0.05);两组患者均未发生严重的不良反应。结论:米索前列醇相比于缩宫素具有更强的促子宫收缩作用,减少产后出血量,降低出血率,使用方法简便,不良反应少,安全性高,适用于预防产后出血,在临床应用过程中可以根据实际情况采用缩宫素联合米索前列醇,达到更好的预防效果。
Objective: To investigate the clinical effect and value of misoprostol in preventing maternal postpartum hemorrhage. Methods: This study retrospectively analyzed the clinical data of 180 pregnant women admitted to our department from March 2012 to April 2013, of which 90 cases were given intravenous injection of 20U oxytocin as the control group after delivery, and 90 Cases of postpartum oral administration of 600ug misoprostol for the observation group compared the two groups of patients with the third stage of labor, 2h and 24h postpartum hemorrhage, postpartum hemorrhage, the incidence of adverse reactions, while observing the two groups of patients before and after treatment of heart rate, Blood pressure changes. Results: The heart rate and blood pressure of the two groups had no significant changes before and after treatment (P> 0.05). The bleeding time of the third stage of labor, 2h and 24h in the observation group was significantly less than that of the control group (P <0.05), and the rate of postpartum hemorrhage was significantly lower than that of the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion: Compared with oxytocin, misoprostol has more effect of promoting uterine contractions, reducing postpartum hemorrhage, reducing bleeding rate, the method is simple, less adverse reactions, high safety, suitable for the prevention of postpartum hemorrhage in the clinical Application process can be based on the actual situation using oxytocin combined with misoprostol, to achieve better prevention.