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恶性黑素瘤起源于表皮黑素细胞,能利用正常细胞发育途径。近期研究显示,某些基因和通路在黑素细胞特化和维持及黑素瘤形成和发展中具有重要作用。本文综述黑素细胞及黑素瘤形成和发展中涉及的信号通路,了解黑素细胞发育过程与肿瘤发展的联系,揭示黑素瘤靶向治疗近期进展和研究潜力。
Malignant melanoma originates in epidermal melanocytes and can utilize normal cellular developmental pathways. Recent studies have shown that certain genes and pathways play an important role in the specialization and maintenance of melanocytes and the formation and development of melanoma. This review summarizes the signaling pathways involved in the formation and development of melanocytes and melanoma and the relationship between the development of melanocytes and the development of melanoma to reveal the recent progress and potential of targeted therapy of melanoma.