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目的观察夫西地酸治疗新生儿葡萄球菌感染的临床疗效,并监测其不良反应。方法 2008年1月至2011年12月收治的各种感染标本分离出葡萄球菌菌株的53例新生儿,男33例,女20例,予夫西地酸钠抗感染治疗,10mg/(kg·次),静脉注射,用输液泵控制速度,注射时2h,一天二次,观察患病新生儿临床症状缓解的时间,同时监测黄疸及肝肾功能。结果 53例患儿,痊愈30例,显效17例,无效3例,总有效率87%,无一例出现肝肾功能异常及胆红素加深。结论夫西地酸抗新生儿葡萄球菌感染疗效好,不良反应少,无肝肾功能的损害,具有临床应用前景。
Objective To observe the clinical efficacy of fusidic acid in the treatment of neonatal staphylococcal infection and monitor its adverse reactions. Methods A total of 53 newborns of Staphylococcus aureus were isolated from various infected specimens from January 2008 to December 2011. There were 33 males and 20 females with antifuscinacytic sodium and 10 mg / (kg · Times), intravenous injection, with infusion pump speed control, injection 2h, twice a day to observe the sick neonates clinical symptoms of relief time, while monitoring jaundice and liver and kidney function. Results 53 cases of children, cured 30 cases, markedly effective in 17 cases, 3 cases were ineffective, the total effective rate was 87%, no case of liver and kidney dysfunction and bilirubin deepened. Conclusion Fusidic acid anti-neonatal staphylococcal infection is effective, less adverse reactions, no damage to liver and kidney function, with clinical application prospects.