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α-干扰素(IFN-α)是一种多效性活性细胞因子,可用雾化吸入法使其达到下呼吸道,且无全身副作用。本文目的是评价肺结核患者雾化吸入IFN-α的疗效。 这是一开放的平行研究。对20例HIV阴性的活动性肺结核患者(排除耐药菌株存在后),随机分为2组,A组10例(女6男4,3例吸烟7例不吸烟,平均年龄31±7岁),B组10例(女5男5,4例吸烟6例不吸烟,平均年龄34±13岁)两组均每天给予异烟肼(INA)5mg/kg、利福平(RAMP)10mg/kg、乙胺丁醇(ETB)15～25mg/kg、吡嗪酰胺(PZ)15～30mg/kg,B组加用雾化吸入α-干扰素(HOIFN-α Ly)(3MU/次,3次/周,共2个月,2个月总量为72MU)。在
Alpha-interferon (IFN-alpha) is a pleiotropic, active cytokine that reaches the lower respiratory tract by nebulization and has no systemic side effects. This article aims to evaluate the efficacy of inhaled IFN-α in patients with pulmonary tuberculosis. This is an open and parallel study. Twenty patients with active HIV-negative pulmonary tuberculosis (excluding the resistant strains) were randomly divided into two groups: group A, 10 patients (6 males, 4 females, 3 cigarettes, 7 non-smokers, mean age 31 ± 7 years) , 10 patients in group B (INA 5 mg / kg, RAMP) 10 mg / kg (INA 5 mg / kg) , Ethambutol (ETB) 15 ~ 25mg / kg and pyrazinamide (PZ) 15 ~ 30mg / kg respectively. In group B, HOIFN-α Ly was administered by inhalation / Week, a total of 2 months, 2 months a total of 72MU). in