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缺血/再灌注损伤已逐渐引起临床重视。研究证实:生理状况下机体可清除少量氧自由基,而病理情况下大量氧自由基的生成超过了机体的防御能力。缺血/再灌注释放的具细胞毒性的氧自由基可损伤心肌,引起再灌注心律失常及抑制心功能。心外科面临着防止缺血/再灌注损伤,改进目前心肌保护方法的问题。针对氧自由基产生与代谢环节,现在主要的防治措施为:①氧自由基清除剂;②黄嘌呤氧化酶抑制剂;③钙拮抗剂;④抗氧化剂;⑤铁离子螯合物;⑥中性粒细胞抑制剂。
Ischemia / reperfusion injury has gradually attracted clinical attention. The study confirmed that: under physiological conditions the body can clear a small amount of oxygen free radicals, while the formation of a large number of oxygen free radicals under the pathological conditions over the body’s defensive ability. Ischemia / reperfusion release of cytotoxic oxygen free radicals can damage the myocardium, causing reperfusion arrhythmia and inhibition of cardiac function. Cardiac surgery faces the problem of preventing ischemia / reperfusion injury and improving current methods of myocardial protection. For the production of oxygen free radicals and metabolic links, the main preventive measures are: ① oxygen free radical scavengers; ② xanthine oxidase inhibitors; ③ calcium antagonists; ④ antioxidants; ⑤ iron chelates; ⑥ neutral Granulocyte inhibitors.