Barrett’s食管(BE)是胃食管反流病(GERD)的并发症,也是食管腺癌(AC)的主要癌前病变。近年来,EA的发病率呈逐年上升趋势,对于BE及BE伴有非典型增生的早期诊断成为研究热点。Fascin蛋白是与肌动蛋白紧密结合的细胞骨架蛋白,LI-cadherin是近年来发现的钙黏蛋白家族中一员,二者能够影响细胞粘附和运动,与肿瘤的生物学行为密切相关。 Barrett’s esophagus (BE) is a complication of gastroesophageal reflux disease (GERD) and is a major precancerous lesion of esophageal adenocarcinoma (AC). In recent years, the incidence of EA showed an upward trend year by year, and the early diagnosis of atypical hyperplasia accompanied by BE and BE has become a hot topic. Fascin protein is a cytoskeleton protein closely associated with actin. LI-cadherin is a member of the cadherin family found in recent years. Both of them can affect cell adhesion and movement, and are closely related to the biological behavior of tumor.