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目的:观察复方斑蝥胶囊联合放疗治疗鼻咽癌的临床效果及不良反应。方法:将2007年6月至2010年12月来我科就诊的120例II、III期低分化鳞状细胞鼻咽癌伴有颈淋巴结转移的患者随机分为复方斑蝥胶囊辅助放疗组、甘氨双唑钠辅助放疗组(阳性对照组)和单纯放疗组(阴性对照组),每组各40例,比较治疗后各组患者的治疗效果和不良反应。结果:各组患者在接受相同放射疗程的情况下,复方斑蝥胶囊辅助放疗组和甘氨双唑钠辅助放疗组的治疗总有效率均明显优于单纯放疗组(P<0.05),但复方斑蝥胶囊辅助放疗组与甘氨双唑钠辅助放疗组比较无明显差异(P>0.05)。复方斑蝥胶囊辅助放疗组皮肤反应的发生率明显低于单纯放疗组(P<0.05);皮肤反应、黏膜反应、口腔溃疡和心电图异常的发生率均明显低于甘氨双唑钠辅助放疗组(P<0.05),但两组恶心呕吐的发生率比较无明显差异(P>0.05)。结论:复方斑蝥胶囊辅助治疗可显著提高放疗治疗鼻咽癌的临床疗效,且无明显毒副作用,值得临床推广应用。
Objective: To observe the clinical effects and adverse reactions of compound cantharidin capsules combined with radiotherapy in the treatment of nasopharyngeal carcinoma. Methods: From June 2007 to December 2010, 120 patients with stage II and III poorly differentiated squamous cell NPC with cervical lymph node metastasis who were treated in our department from June 2007 to December 2010 were randomly divided into compound radix scutellariae radiotherapy group, Metronidazole adjuvant radiotherapy group (positive control group) and radiotherapy alone group (negative control group), 40 cases in each group. The treatment effect and adverse reactions in each group were compared. Results: The total effective rates of the compound cantharidin capsule adjuvant radiotherapy group and the glycopyrrolate sodium adjuvant radiotherapy group were significantly better than those of the radiotherapy alone group (P <0.05) under the same radiotherapy course. However, Capsule adjuvant radiotherapy group and glycopyrrolate adjuvant radiotherapy group no significant difference (P> 0.05). The incidence of skin reactions in the compound cantharidin capsule radiotherapy group was significantly lower than that of the radiotherapy alone group (P <0.05). The incidences of skin reactions, mucosal reactions, oral ulcer and electrocardiogram abnormalities were significantly lower than those of the glycradiradiol adjuvant radiotherapy group P <0.05), but there was no significant difference in the incidence of nausea and vomiting between the two groups (P> 0.05). Conclusion: The compound canthaxillary capsule adjuvant therapy can significantly improve the clinical efficacy of radiotherapy for the treatment of nasopharyngeal carcinoma, and no obvious side effects, it is worthy of clinical application.