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目的 探讨P2 7kip1蛋白在胆管癌组织中的表达及其与浸润转移的关系。方法 采用免疫组化方法 ,检测 49例胆管癌及 8例正常胆管组织中P2 7kip1蛋白的表达情况。结果 胆管癌及正常胆管组织中P2 7kip1蛋白阳性表达率分别为 40 82 %和 87 5 0 % ,P2 7kip1蛋白的表达与胆管癌有无淋巴结转移或远处转移及TNM分期呈显著相关 (P <0 0 1)。结论 P2 7kip1蛋白的表达降低或缺失可能在胆管癌浸润转移过程中发挥作用。
Objective To investigate the expression of P2 7kip1 protein in cholangiocarcinoma and its relationship with invasion and metastasis. Methods Immunohistochemical method was used to detect the expression of P2 7kip1 protein in 49 cases of cholangiocarcinoma and 8 cases of normal bile duct tissue. Results The positive rates of P2 7kip1 protein in cholangiocarcinoma and normal bile duct tissue were 4082% and 875%, respectively. The expression of P2 7kip1 protein was significantly correlated with lymph node metastasis or distant metastasis and TNM staging of cholangiocarcinoma (P < 0 0 1). Conclusion The decrease or deletion of P2 7kip1 protein may play a role in the invasion and metastasis of cholangiocarcinoma.