人类 β珠蛋白基因簇的顺次切换表达机制包括 :在转录水平多个转录调控元件如 L CR、EKL F、CCAAT等的作用 ,在转录后各 m RNA的翻译及加工也受到影响。而 α珠蛋白基因簇的切换机制则为 ζ基因的关闭。另外 ,α及 β- m RNA3′U TR结构对其自身稳定性具有决定性作用 ,并进而影响其蛋白质水平。 The mechanism of sequential switching of human β-globin gene cluster includes the action of multiple transcriptional regulatory elements such as LCR, EKL F and CCAAT at the transcriptional level, and the translation and processing of each m RNA after transcription are also affected. The α-globin gene cluster switching mechanism is ζ gene shut down. In addition, the α and β-m RNA3’U TR structures have a decisive effect on their own stability, which in turn affects their protein levels.