目的 :研制包裹有化疗药物的颗粒型可降解性栓塞剂。方法 :采用改良的双相乳化冷凝聚合法制备5 - Fu明胶微球 ,并测试了微球的包裹率、载药率及体外释药特性。结果 :5 - Fu明胶微球颗粒直径均匀 ,药物包裹率 85 % ,载药率 12 .2 % ,体外 4h内缓释 95 %。结论 :制得的多种直径的 5 - Fu明胶微球性质稳定 ,微球降解速率及药物释放速度基本符合临床要求 Objective: To develop particulate degradable embolic agents encapsulated with chemotherapy drugs. Methods: The modified 5-micron gelatin microspheres were prepared by a modified two-phase emulsification condensation polymerization method. The microspheres were tested for their encapsulation efficiency, drug loading and in vitro release characteristics. Results : The diameter of 5 - Fu gelatin microspheres was uniform, the drug entrapment rate was 85%, the drug loading rate was 12.2%, and the release rate was 95% in vitro within 4 hours. Conclusion : The prepared 5 - Fu gelatin microspheres with various diameters are stable, the degradation rate of microspheres and the drug release rate are basically in line with the clinical requirements.