临床研究发现,动脉粥样硬化多发生于血管弯曲和分叉处。这些区域呈现切应力较低、变化幅度较大的特点。近年的体内外研究也表明血管内皮细胞不仅能够对均匀流体切应力的大小变化作出反应,也能感受流体切应力的空间梯度,即非均匀流体切应力的影响。动脉粥样硬化不仅与较低的切应 Clinical research found that atherosclerosis occurred in the vascular curvature and bifurcation. These areas show the characteristics of low shear stress and large variation. In recent years, in vitro and in vivo studies have also shown that vascular endothelial cells can not only respond to changes in the size of uniform fluid shear stress, but also the spatial gradient of fluid shear stress, ie, the effect of inhomogeneous fluid shear stress. Atherosclerosis is not only associated with lower cuts