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95%氟吗啉原药对Wistar大鼠 1 3周经口喂饲毒性研究结果表明 :30 0 0mg/kg及50 0 0mg/kg浓度组雄鼠体重增长受到不同程度的抑制 ,肝脏也出现不同程度的肿大 ,肝功能异常 ,全部雄鼠肝小叶中心部的肝细胞肿大 ;50 0 0mg/kg浓度组雄鼠还表现为平均摄食量减少 ,食物利用率下降 ,肾功能异常 ,并有 1只雄鼠步态异常、双后肢及爪部红肿。 30 0 0mg/kg及 50 0 0mg/kg浓度组雌鼠体重增长受到抑制 ,摄食量减少 ,食物利用率下降 ,肝脏肿大 ,肝功能异常 ,并有贫血倾向 ;50 0 0mg/kg浓度组雌鼠还表现为肾功能异常 ,脾脏也有肿大趋势 ,共有 5只雌鼠步态异常、后肢及爪部红肿。 60 0mg/kg浓度组雌鼠肝功能异常 ,并有贫血倾向。 60 0mg/kg浓度组雄鼠及1 2 0mg/kg浓度组雄雌鼠各项检查指标均未见有意义的试验结果。即 95%氟吗啉原药对Wistar大鼠 1 3周经口喂饲染毒最大无作用浓度雄性为 60 0mg/kg ;雌性为 1 2 0mg/kg。
95% Fluoromorph original drug Wistar rats 1 3 weeks oral feeding toxicity study showed that: 30 0 0mg / kg and 50 0 0 mg / kg concentration group male rats weight gain was inhibited to varying degrees, the liver also appears different Degree of enlargement, abnormal liver function, hepatocellular enlargement in the center of hepatic lobule in all male rats; the male rats at the concentration of 500 mg / kg also showed decreased average food intake, decreased food utilization, abnormal renal function and One male mouse had an abnormal gait, and both hindlimbs and claws were swollen. The body weight gain of 30 0 0 mg / kg and 50 0 0 mg / kg was inhibited, the food intake decreased, the food utilization decreased, the liver enlarged and the liver function abnormal. Rats also showed abnormal renal function, the spleen also have swelling trend, a total of five female gait abnormalities, hindlimbs and claw Ministry of swelling. The females at 60 mg / kg concentration had abnormal liver function and anemia. No significant test results were found in the test indexes of male and female rats at a concentration of 60 mg / kg and male and female rats at a concentration of 120 mg / kg. Namely, 95% of the original fluoxetine in Wistar rats 1 3 weeks oral feeding maximum toxic concentration of male 60 0mg / kg; female 120mg / kg.