心脏交感神经分布的改变可引起Q-T间期延长,并易致急性心律失常和猝死,有自主神经病变的糖尿病病人可发生心脏性猝死,但其原因尚不明确。 作者对30例无临床心脏病证据的胰岛素依赖型糖尿病病人进行了研究。其中女20人,男10人,年龄19～53岁(平均33岁),病程10～28年(平均17年),试验前24～48小时停用胰岛素以外的所有药物。采用5种非侵入性自主神经功能试验测定病人的心脏自主神经病变,包括静息脉搏、每分钟最小与最大心率之差、瓦氏动作、立位心率反应及站立 Changes in the distribution of sympathetic heart can cause Q-T interval prolongation, and easy to cause acute arrhythmia and sudden death, diabetic patients with autonomic neuropathy can occur sudden cardiac death, but the reason is not yet clear. The authors studied 30 patients with insulin-dependent diabetes mellitus without clinical evidence of heart disease. Among them, 20 were women and 10 were males. Their ages ranged from 19 to 53 years (average 33 years). Their duration of illness ranged from 10 to 28 years (mean 17 years). All drugs except insulin were discontinued 24-48 hours before the test. Five noninvasive autonomic neurological tests were used to measure cardiac autonomic neuropathy in patients, including resting pulse, difference between minimum and maximum heart rate per minute, Valsalva’s action, standing heart rate response and standing