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药物吸收是指药物自给药部位摄取进入血液循环的过程。药物的吸收速率,是药代动力学和生物利用度研究的一个重要参数(美国食品药品管理局曾提出,如方法允许,要对所有新处方药物测定生物利用度)。吸收速率对血药浓度影响很大,它受给药途径和许多其它因素的影响。给药途径不同,吸收速率自然不同;剂型不同,吸收速率亦各异。如固体剂型的口服吸收,就取决于制剂的崩解、活性药物的溶出、在吸收部位的药物浓度和血液循环,以及吸收面的位置和面积。若药物不吸收,当然不能起全身作用;如果吸收差,则必须加大剂量;要是吸收慢,可能作用会延迟;吸收过快,可发生副作用;吸收不规则,又
Drug absorption refers to the process of ingestion of drug self-administered into the blood circulation. The rate of drug absorption is an important parameter in pharmacokinetic and bioavailability studies (the FDA has proposed that the bioavailability be determined for all new prescription drugs, as the method allows). The rate of absorption has a large effect on plasma concentration, which is influenced by the route of administration and many other factors. Different routes of administration, the absorption rate of natural different; different dosage forms, the absorption rate is also different. For example, the oral absorption of a solid dosage form depends on the disintegration of the formulation, dissolution of the active drug, drug concentration and blood circulation at the absorption site, and the location and area of the absorption surface. If the drug does not absorb, of course, can not play the role of the whole body; if poor absorption, you must increase the dose; if slow absorption may delay; absorption too fast, side effects can occur; absorption irregular