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应用免疫组化技术研究４６例胃癌手术切除新鲜标本及其引流区域淋巴结中Ⅳ型胶原酶的表达，以探索其在胃癌浸润转移中的作用。结果发现：Ⅳ型胶原酶存在于正常胃小凹上皮和胃癌中，但在５７％（２６／４６）胃癌中的表达增强（Ｐ＜０．０１），而且在有些胃癌组织浸润前缘其表达增强，在胃癌原发灶中Ⅳ型胶原酶的表达和淋巴结转移灶中的表达一致。另外，在有淋巴结转移的胃癌原发灶中，Ⅳ型胶原酶的表达较无淋巴结转移的胃癌原发灶中的表达明显增强（Ｐ＜０．０１）．实验表明，Ⅳ型胶原酶可能与胃癌浸润转移密切相关，它可以作为判断胃癌浸润转移恶性表型的有用生物学标志。
Immunohistochemical technique was used to study the expression of type IV collagenase in fresh specimens of 46 patients with gastric cancer after surgical resection and to explore its role in the invasion and metastasis of gastric cancer. The results showed that type IV collagenase was present in normal gastric pit epithelium and gastric cancer, but its expression was increased in 57% (26/46) of gastric cancer (P<0.01), and it was expressed in the infiltration margin of some gastric cancer tissues. The expression of type IV collagenase in primary gastric cancer was consistent with that in lymph node metastases. In addition, in the primary gastric cancer with lymph node metastasis, the expression of type IV collagenase was significantly higher than that of primary gastric cancer without lymph node metastasis (P<0.01). Experiments show that type IV collagenase may be closely related to the invasion and metastasis of gastric cancer. It can be used as a useful biological marker to judge the malignant phenotype of gastric cancer.