1965年Vassalli 和MeCluskey 首次提出凝血、纤维蛋白沉积是肾小球疾病的表现之一,并假设肝素治疗可能有效。20年来,在肾小球疾病中抗凝及纤溶治疗的应用已较广泛。纤溶与凝血是对立统一的二个侧面,可因同一因子始动激活,两系统间也交叉存在着相互促进和抑制 In 1965, Vassalli and MeCluskey first proposed coagulation. Fibrin deposition is one of the manifestations of glomerular diseases and assumes that heparin therapy may be effective. In 20 years, the application of anticoagulant and fibrinolytic therapy in glomerular diseases has been more extensive. Fibrinolysis and coagulation are the two sides of the unity of opposites, which can be activated by the same factor, and the mutual promotion and inhibition exist between the two systems