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目的：观察双嘧达莫对小鼠免疫功能的影响。方法：采用小鼠末梢血白细胞计数，脾脏称重计算脾脏系数，测小鼠足垫厚度的差值确定小鼠迟发型超敏反应，用ＰＨＡ和ＣｏｎＡ诱生的脾淋巴细胞增殖测定淋巴细胞转化功能，作为活化的小鼠脾细胞测定小鼠ＩＬ－２的活性。结果：双嘧达莫１，１０，４０ｍｇ／ｋｇ抑制小鼠的迟发型超敏反应，降低小鼠末梢血白细胞计数和脾脏系数。双嘧达莫（Ｄｉｐ），１，１０，１００，１０００μｍｏｌ／Ｌ抑制ＰＨＡ诱导的小鼠脾淋巴细胞转化和ＣｏｎＡ诱导的小鼠脾淋巴细胞增殖反应，Ｄｉｐ１，１０，１００μｍｏｌ／Ｌ亦抑制小鼠脾细胞产生ＩＬ－２。结论：实验结果为Ｄｉｐ老药新用提供一定的理论依据，临床上Ｄｉｐ应用于一些免疫性疾病的治疗似有较大潜力。
Objective: To observe the effect of dipyridamole on immune function in mice. Methods: The mouse model of delayed-type hypersensitivity was established by calculating the peripheral blood leukocyte count, spleen weighing spleen coefficient, measuring the difference of footpad thickness, and measuring the lymphocyte transformation by PHA and ConA induced spleen lymphocyte proliferation Function as murine spleen cells as measured in mouse IL-2 activity. Results: Dipyridamole 1, 10, 40 mg / kg inhibited the delayed-type hypersensitivity in mice and decreased the peripheral blood leukocyte count and spleen coefficient in mice. Dipyridamole (Dip), 1,10,100,1000μmol / L inhibited the PHA-induced mouse splenic lymphocyte transformation and ConA-induced mouse splenic lymphocyte proliferation. Dip1,10,100μmol / L also inhibited mice Spleen cells produce IL-2. Conclusion: The experimental results provide a new theoretical basis for the new use of Dip old drugs. It seems that clinical application of Dip in the treatment of some immune diseases seems to have great potential.