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目的分析该院在抗生素专项整治活动开展后铜绿假单胞菌(Pseudomonas aeruginosa,PEA)的临床分布及耐药趋势。方法对该院2014年7月—2015年4月临床标本分离出的2 167株铜绿假单胞菌进行临床分布及耐药趋势分析。结果共检出铜绿假单胞菌2 167株,占细菌总数的22.41%(2 167/9 669)。分布部位:呼吸道分离率最高,占总分离率的88.05%。主要分布科室:重症监护病房、老年病病房、呼吸内科病房(84.13%)。对13种抗菌药物的耐药率均>50%。随着抗生素专项整治活动的展开,其检出率和构成比已呈现出逐渐下降的趋势。耐药率月趋势:除米诺环素的耐药率无明显下降外,对β-内酰胺类,喹诺酮类、氨基糖甙类抗生素抗菌药物的耐药率均有明显下降。结论该医院的铜绿假单胞菌主要分布于重症监护病房、老年病病房、呼吸内科病房,提高抗菌药物的临床管理水平能有效防止耐药菌在医院的流行和播散。
Objective To analyze the clinical distribution and drug resistance of Pseudomonas aeruginosa (PEA) in this hospital after the special rectification activities of antibiotics. Methods The clinical distribution and drug resistance trend of 2 167 strains of Pseudomonas aeruginosa isolated from clinical specimens from July 2014 to April 2015 in the hospital were analyzed. Results A total of 2 167 strains of Pseudomonas aeruginosa were detected, accounting for 22.41% (2 167/9 669) of the total number of bacteria. Distribution sites: the highest rate of respiratory separation, the total separation rate of 88.05%. The main distribution sections: intensive care unit, geriatric ward, respiratory ward (84.13%). Resistance to 13 kinds of antibacterials were> 50%. With the launching of special rectification activities of antibiotics, the detection rate and composition ratio have shown a gradual downward trend. Drug resistance monthly trend: except for minocycline resistance rate no significant decline, the β-lactams, quinolones, aminoglycoside antibiotics antimicrobial resistance rates were significantly decreased. Conclusion The Pseudomonas aeruginosa in this hospital mainly distributes in ICU, geriatric ward and respiratory medicine ward, and improving the clinical management level of antibacterials can effectively prevent the spread and spread of resistant bacteria in the hospital.