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本文报道28例新生儿期发病的巨细胞病毒性肺炎,均系根据:(1)新鲜尿液沉渣检查在脱落的肾上皮细胞内找到典型核内包涵体(猫头鹰眼);(2)具有肺间质炎症改变为特征的临床与X线表现。其中男:女为21:7。发病日龄≤7天16例,8～28天12例。起病症状咳嗽伴呼吸困难9例,黄疸伴呼吸困难或腹泻19例。临床表现黄疸28例,呼吸困难25例,咳嗽16例,有发热者15例。肺部有体征表现者仅11例。X线胸片均有网状、颗粒状改变并伴有肺野透亮度增高、局灶性肺气肿等间质改变,其中1例X线有团块及空腔改变。作者认为限于目前尚不能广泛开展肺活检或肺穿刺以进行病毒培养的情况下,对有可疑巨细胞病毒感染之新生儿,具特征的肺间质炎症临床表现及X线所见,结合尿液沉渣检查,仍可作为临床诊断的主要手段。
This article reports 28 cases of neonatal viral cytomegalovirus pneumonia, are based on: (1) fresh urine sediment examination in exfoliated renal epithelial cells to find a typical nuclear inclusions (owl eye); (2) with lung Interstitial inflammatory changes are characterized by clinical and radiographic manifestations. Among them, male: female 21: 7. The onset day ≤ 7 days in 16 cases, 8 to 28 days in 12 cases. Symptoms cough with dyspnea in 9 cases, jaundice with dyspnea or diarrhea in 19 cases. Clinical manifestations of jaundice in 28 cases, 25 cases of dyspnea, cough in 16 cases, 15 cases of fever. Only 11 cases of lung manifestations were signs. X-ray films were reticular, granular changes accompanied by increased lung brightness, focal emphysema and other interstitial changes, including 1 case of X-ray clumps and the cavity changes. The authors believe that limited to the present can not be widely carried out lung biopsy or lung biopsy for the case of virus culture, suspected cysticercus virus infection in neonates, the clinical manifestations of interstitial lung inflammation and X-ray findings, combined with urine Sediment inspection, can still be used as the main means of clinical diagnosis.