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目的分析原发醛固酮增多症不同亚型的实验室检查结果差异。方法 92例原发醛固酮增多症患者,依据术后组织病理结果分为肾上腺腺瘤组(76例)和肾上腺增生组(16例),比较2组血钾、血钠、血醛固酮、肾素、血管紧张素Ⅱ和醛固酮肾素比值。结果增生组血钾水平((3.78±0.38)mmol/L)高于腺瘤组((3.34±0.66)mmol/L)(P<0.05),血钠、血醛固酮、肾素、血管紧张素Ⅱ及醛固酮肾素比值((143.61±2.45)mmol/L、13.5(6.8,245.0)ng/(L·h)、(0.66±0.72)mg/L、(36.90±23.37)ng/L、170.0(7.7,9 450.0))与腺瘤组((144.53±3.16)mmol/L、21.2(2.1,375.0)ng/(L·h)、(0.62±1.23)mg/L、(33.84±24.51)ng/L、111.0(2.1,6 820.0))比较差异无统计学意义(P>0.05)。结论原发醛固酮增多症肾上腺腺瘤和肾上腺增生患者临床表现相似,术前检测血钾有助于亚型判定。
Objective To analyze the difference of laboratory test results of different subtypes of primary aldosteronism. Methods Ninety-two patients with primary aldosteronism were divided into adrenal adenoma group (76 cases) and adrenal hyperplasia group (16 cases) according to histopathological results. The levels of serum potassium, serum sodium, serum aldosterone, renin, Angiotensin II and aldosterone renin ratio. Results The level of serum potassium (3.78 ± 0.38 mmol / L) in hyperplasia group was significantly higher than that in adenoma group (3.34 ± 0.66 mmol / L) (P <0.05), serum sodium, serum aldosterone, renin, angiotensin Ⅱ And aldosterone renin ((143.61 ± 2.45) mmol / L, 13.5 (6.8,245.0) ng / (L · h), (0.66 ± 0.72) mg / L, (36.90 ± 23.37) ng / L and 170.0 , 9 450.0) and adenoma group (144.53 ± 3.16) mmol / L, 21.2 (2.1,375.0) ng / (L · h), (0.62 ± 1.23) mg / L and (33.84 ± 24.51) ng / L , 111.0 (2.1,6 820.0)), there was no significant difference (P> 0.05). Conclusion Primary aldosteronism adrenal adenomas and adrenal hyperplasia clinical manifestations of patients with similar, preoperative serum potassium to help determine the subtype.