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目的：探讨血管内皮生长因子（ｖｅｓｃｕｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｇｒｏｔｈ ｆａｃｔｏｒ， ＶＥＧＦ）在血管生成及其在卵巢癌发展中的作用。方法：用免疫组织化学方法检测ＶＥＧＦ在７９例人卵巢上皮性癌组织中的表达，并标记肿瘤内血管，分析ＶＥＧＦ与瘤内微血管密度（ｍｉｃｒｏｖｅｓｓｅｌ ｄｅｎｓｉｔｙ， ＭＶＤ）及其与组织学分类、临床分期。腹水、淋巴结转移、预后的关系。结果：在７９例卵巢上皮性癌中５０例（６３．３％）ＶＥＧＦ表达阳性。ＶＥＧＦ染色阳性者的ＭＶＤ均值显著高于ＶＥＧＦ阴性者（Ｐ＜ ０．０１）。在晚期卵巢癌（ Ｐ＜ ０．０１）、大量腹水（ Ｐ＜ ０． ０５）和腹水细胞学阳性（Ｐ＜ ０．０２５）者中 ＶＥＧＦ表达阳性率显著增高。ＶＥＧＦ阳性患者的５年生存率低于ＶＥＧＦ阴性患者。ＶＥＧＦ表达与卵巢癌组织学分类及淋巴结转移无关（Ｐ＞０.０５）。结论：ＶＥＧＦ与卵巢癌血管生成密切相关。ＶＥＧＦ在卵巢癌的发展中起着重要作用。检测肿瘤中ＶＥＧＦ的表达有助于了解卵巢癌的生物学特性，为患者提供预后信息。
Objective: To investigate the role of vascular endothelial growth factor (VEGF) in angiogenesis and its role in the development of ovarian cancer. Methods: The expression of VEGF in 79 cases of human ovarian epithelial carcinoma was detected by immunohistochemistry, and the intravascular tumors were labeled. The relationship between VEGF and microvessel density (MVD) and its histological classification, clinical stage . Ascites, lymph node metastasis, prognosis. Results: In 79 cases of epithelial ovarian cancer, 50 cases (63.3%) had positive VEGF expression. The mean MVD of VEGF-positive patients was significantly higher than that of VEGF-negative patients (P <0.01). The positive rate of VEGF expression in advanced ovarian cancer (P <0.01), large amount of ascites (P <0.05) and ascites cytology (P <0.025) was significantly higher. The 5-year survival rate of VEGF-positive patients is lower than that of VEGF-negative patients. VEGF expression had no correlation with histological classification and lymph node metastasis (P> 0.05). Conclusion: VEGF is closely related to angiogenesis in ovarian cancer. VEGF plays an important role in the development of ovarian cancer. Detecting the expression of VEGF in tumors helps to understand the biological characteristics of ovarian cancer and provide prognostic information to patients.