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长链非编码RNA(lncRNAs)是一类长度>200 nt且因缺乏开放性阅读框架而不能编码蛋白质的转录本。然而lncRNAs能够在转录以及转录后水平上以多种方式参与调控肿瘤的发生发展。膀胱癌相关转录因子1(BLACAT1)作为一个lncRNA，定位于人类染色体1q32.1，在多种恶性肿瘤(膀胱癌、胃癌、肺癌等)中异常表达，并能够通过不同的机制调控肿瘤细胞增殖、抗凋亡、侵袭和转移，影响肿瘤的发生发展。本文就BLACAT1在恶性肿瘤中的作用及机制作一综述。“,”Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors.