单剂疫苗的效力能有助于控制由传染病引起的死亡 ,而保护作用只能通过反复免疫接种合适的疫苗获得。为能达到此目的 ,可生物降解微球 ( MS)疫苗已进入临床前研究。　　作者制备了 9种负载破伤风类毒素( TT,1 Lf)的可生物降解 MS,分别皮下接种2 50～ 30 0 g的豚鼠 1次 ,同时以 1 The efficacy of a single dose of vaccine can help control the deaths caused by an infectious disease, and protection can only be achieved by repeated immunizations with the appropriate vaccine. To achieve this goal, biodegradable microspheres (MS) vaccine has entered the preclinical study. The authors prepared 9 biodegradable MS loaded with tetanus toxoid (TT, 1 Lf), subcutaneously inoculated guinea pigs in the range of 250 to 300 g once, respectively, and 1