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本研究测定了克隆氏病(CD)患者的血清甲状腺素(T_4)、三碘甲腺原氨酸(T_3)和反 T_3(rT_3)浓度,以估价严重肠道疾病对甲状腺素的外周组织脱碘作用的影响。此外,尚测定了血清甲状腺结合球蛋白(TBG)的浓度,因 CD 患者虽然甲状腺功能正常但TBG 浓度上升可引起总 T_4浓度升高。本组23例(男15,女8)CD 患者,病程1～23年,在研究期间接受不同药物治疗(如糖皮质激素,硫唑嘌呤等)。对照组为25名甲状腺功能正常的健康人。结果 CD 组平均 T_4为7.7±2.2μg%,与对照组的7.2±1.2μg%无差异(P>0.05),TBG 浓度为23.7±6.9μg/ml,与对照组的21.9±3.6μg/ml 相
In this study, serum thyroxine (T_4), triiodothyronine (T_3) and anti-T_3 (rT_3) concentrations were measured in patients with Crohn’s disease (CD) to assess the effect of thyroid hormone on the peripheral tissues of patients with severe intestinal diseases Effect of iodine effect. In addition, the serum thyroid binding globulin (TBG) concentration was measured, because CD patients with normal thyroid function but TBG concentration can cause increased total T 4 concentration. The group of 23 patients (male 15, female 8) CD patients, duration of 1 to 23 years, during the study were treated with different drugs (such as glucocorticoids, azathioprine, etc.). The control group consisted of 25 healthy healthy people with normal thyroid function. Results The average T_4 of CD group was 7.7 ± 2.2μg%, which was no significant difference from that of the control group (7.2 ± 1.2μg%) (P> 0.05). The TBG concentration was 23.7 ± 6.9μg / ml,