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目的探究幽门螺杆菌(Hp)感染与复发性过敏性紫癜之间的相关性。方法 60例复发性过敏性紫癜患儿作为观察组,60例体检的健康儿童作为对照组,对两组受检对象进行Hp检测,对比两组患儿的Hp阳性率,对比观察组Hp阳性与阴性患儿的腹痛发生率。观察组60例患儿根据Hp检测结果将分为Hp阳性和Hp阴性中,其中Hp阳性中部分患儿未采用抗Hp治疗,仅单一采用常规过敏性紫癜治疗,设为A组,其余Hp阳性患儿采用抗Hp治疗+常规过敏性紫癜治疗,设为B组;Hp阴性患儿采用常规过敏性紫癜治疗,设为C组。对比三组患儿的治疗总有效率。结果观察组患儿的Hp阳性率71.67%明显高于对照组健康儿童的25.00%,差异有统计学意义(P<0.05);观察组中Hp阳性患儿的腹痛发生率69.77%高于Hp阴性患儿的41.18%,差异有统计学意义(P<0.05);A组患儿的治疗总有效率75.00%明显低于B组的95.65%和C组的88.24%,差异有统计学意义(P<0.05)。结论 Hp感染与复发性过敏性紫癜的发病之间存在一定的相关性,Hp感染可能诱发过敏性紫癜的复发,在临床治疗中还需加强抗Hp治疗,改善预后,预防病情的反复发作。
Objective To investigate the correlation between Helicobacter pylori (Hp) infection and recurrent anaphylactoid purpura. Methods Sixty children with recurrent anaphylactoid purpura were selected as the observation group and 60 healthy children as the control group. Hp was detected in two groups of subjects, Hp positive rate was compared between the two groups, Hp positive and Negative children with abdominal pain incidence. According to the results of Hp test, 60 children in the observation group were divided into Hp positive and Hp negative, some of which were not treated with anti-Hp in the positive part of Hp, and were treated with conventional allergic purpura alone. The other Hp positive Children with anti-Hp therapy + conventional allergic purpura treatment, set to B group; Hp-negative children with conventional allergic purpura treatment, set to C group. The total effective rate was compared between three groups of children. Results The positive rate of Hp in observation group was 71.67%, which was significantly higher than that in control group (25.00%) (P <0.05). The incidence of abdominal pain in Hp positive children in observation group was 69.77% higher than that in Hp negative The difference was statistically significant (P <0.05). The total effective rate of treatment group A was 75.00%, which was significantly lower than 95.65% in group B and 88.24% in group C, the difference was statistically significant (P <0.05). Conclusion There is a correlation between Hp infection and recurrent anaphylactoid purpura. Hp infection may induce the recurrence of anaphylactoid purpura. Anti-Hp treatment should be strengthened to improve the prognosis and prevent recurrent illness.