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近20年来的资料说明斑秃乃是一种免疫性疾病。从而排除了寄生(真菌或细菌)、神经营养及内分泌等假说。本文作者从下列几方面复习了可能引起斑秃的重要致病因素: 一、遗传学:斑秃常具有阳性的家族史,家庭发病约占25%。再加上有两对同卵双生男孩几乎是在同时间同部位发生斑秃的报告,提示本病具有遗传倾向。且不同的人种似有不同的HLA成分与本病的发生有关(芬兰人HLA-B12、犹太人HLA-B18)。二、免疫学:免疫病因的证据来自三个
Nearly 20 years of data show that alopecia areata is an immune disease. Thus eliminating the parasitic (fungi or bacteria), neurotrophic and endocrine and other hypotheses. The authors review the following important aspects of alopecia areata may cause: First, genetics: alopecia areata often have a positive family history, family incidence of about 25%. Coupled with two pairs of identical twins almost at the same time with the occurrence of alopecia areata in the report, suggesting that the disease has a genetic predisposition. And different races seem to have different HLA components related to the occurrence of this disease (Finnish HLA-B12, Jew HLA-B18). Second, immunology: evidence of immune etiology from three