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目的为防治耐甲氧西林葡萄球菌医院感染。方法调查华山医院１９９５年临床分离到葡萄球菌的住院患者的临床资料，并收集了临床分离菌株，以琼脂双倍稀释法测定细菌药敏。结果发现８７．８％的金葡菌感染和８２．４％的凝固酶阴性葡萄球菌（ＣＮＳ）感染属医院感染，引起医院感染的金葡菌和ＣＮＳ对甲氧西林的耐药率分别为９２．１％和６２．９％。金葡菌感染多发于下呼吸道（４２．６％）和尿路（２０％）。结论ＣＮＳ可引起尿路、血液、静脉留置针有关的感染。体外药敏试验显示葡萄球菌大多呈多重耐药。患有严重基础疾病、接受介入诊疗操作、应用第三代头孢菌素、氟喹诺酮类药物和免疫抑制剂、住院时间长等可能是葡萄球菌医院感染的危险因素。控制这些因素可望减少此类感染的发病
The purpose is to prevent methicillin-resistant Staphylococcus nosocomial infection. Methods The clinical data of hospitalized patients with staphylococci clinically isolated from Huashan Hospital in 1995 were collected and clinically isolated strains were collected. Susceptibilities to bacteria were determined by agar double dilution method. The results showed that 87.8% of Staphylococcus aureus infections and 82.4% of coagulase-negative Staphylococcus (CNS) infections were nosocomial infections. The rates of resistance to S. aureus and CNS to methicillin-causing nosocomial infections were 92 .1% and 62.9%. Staphylococcus aureus infection in the lower respiratory tract (42.6%) and urinary tract (20%). Conclusion CNS can cause urinary tract, blood, vein-related needle-related infections. In vitro susceptibility testing showed that most of the staphylococci were multi-drug resistant. Patients with severe underlying diseases, interventional procedures, third-generation cephalosporins, fluoroquinolones and immunosuppressive agents, and long hospital stays may be risk factors for nosocomial infections in staphylococci. Controlling these factors is expected to reduce the incidence of such infections