选择有引产指征，无阴道分娩禁忌证及应用米索前列醇禁忌证的单胎头位住院孕妇１２０例，随机分为米索组、催产素组各６０例。用药前按Ｂｉｓｈｏｐ评分方法进行宫颈成熟度评分。结果：米索组引产有效率（９６．６７％）明显高于催产素组（４３．３３％）；引产后２４ｈ内分娩米索组（９１．６７％）明显高于催产素组（２１．６７％）；米索组在低宫颈评分为（＜６）引产效果（９５．８３％）明显高于催产素组（１３．０４％）。两组新生儿Ａｐｇａｒ评分、出血量、胎心音变化差异均无显著性。认为米索前列醇用于晚期妊娠引产安全、有效、用药方便。 A total of 120 pregnant women with single fetus in hospital were enrolled in this study. They were randomly assigned to the misoprostol and oxytocin groups of 60 cases. Cervical maturity scores were scored according to the Bishop method before treatment. Results: The effective rate of misoprostol induction (96.67%) was significantly higher than that of oxytocin (43.33%). The misoprostol (91.67%) was significantly higher than that of oxytocin within 24 hours after induction of labor. 67%). The misoprostol was lower in the misoprostol group (<6) (95.83%) than in the oxytocin group (13.04%). There was no significant difference in Apgar score, bleeding volume and fetal heart sound between the two groups. Misoprostol for late pregnancy induction of labor is safe, effective, convenient medication.